Aortic dissection is an uncommon but potentially lethal complication that can occur during the engagement of a guiding catheter. We report a case of a 59-year-old woman with acute aortic dissection due to percutaneous coronary intervention. This resulted in a retrograde extension of the dissection into the proximal part of the ascending aorta. With haemodynamic stability, we decided to treat the aortic dissection medically. As a result, a complete resolution of the aortic dissection was documented by coronary angiography and the follow-up computed tomography scan.