Abstract
Three new bicyclic C(21) terpenoids, clathric acid (1) and two N-acyl taurine derivatives, clathrimides A (2) and B (3), were isolated from the marine sponge Clathria compressa. The structures of these compounds were elucidated by interpretation of spectroscopic data. Clathric acid showed mild antibacterial activity against several Gram-positive bacteria.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Gram-Positive Bacteria / drug effects
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Marine Biology
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Microbial Sensitivity Tests
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Molecular Structure
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Oceans and Seas
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Porifera / chemistry*
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Terpenes / chemistry
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Terpenes / isolation & purification*
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Terpenes / pharmacology
Substances
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Anti-Bacterial Agents
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Terpenes
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clathric acid
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clathrimide A
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clathrimide B