Multiple binding modes of inhibitors to carbonic anhydrases: how to design specific drugs targeting 15 different isoforms?

Chem Rev. 2012 Aug 8;112(8):4421-68. doi: 10.1021/cr200176r. Epub 2012 May 18.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Carbonic Anhydrase Inhibitors / chemistry
  • Carbonic Anhydrase Inhibitors / metabolism*
  • Carbonic Anhydrase Inhibitors / pharmacology*
  • Carbonic Anhydrases / chemistry
  • Carbonic Anhydrases / metabolism*
  • Drug Design*
  • Humans
  • Isoenzymes / antagonists & inhibitors
  • Isoenzymes / chemistry
  • Isoenzymes / metabolism
  • Molecular Sequence Data
  • Protein Binding
  • Zinc / metabolism

Substances

  • Carbonic Anhydrase Inhibitors
  • Isoenzymes
  • Carbonic Anhydrases
  • Zinc