Abstract
Decreased blood-brain barrier P-glycoprotein (Pgp) function has been shown in Alzheimer's disease (AD) patients using positron emission tomography (PET) with the radiotracer (R)-[(11)C]verapamil. Decreased Pgp function has also been hypothesized to promote cerebral amyloid angiopathy (CAA) development. Here, we used PET and (R)-[(11)C]verapamil to assess Pgp function in eighteen AD patients, of which six had microbleeds (MBs), presumably reflecting underlying CAA. No differences were found in binding potential and nonspecific volume of distribution of (R)-[(11)C]verapamil between patient groups. These results provide no evidence for additional Pgp dysfunction in AD patients with MBs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism*
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Aged
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Alzheimer Disease / complications
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Alzheimer Disease / diagnostic imaging
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Alzheimer Disease / metabolism*
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Blood-Brain Barrier / diagnostic imaging
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Blood-Brain Barrier / metabolism*
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Carbon Radioisotopes
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Cerebral Amyloid Angiopathy / diagnostic imaging
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Cerebral Amyloid Angiopathy / etiology
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Cerebral Amyloid Angiopathy / metabolism*
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Cerebral Hemorrhage / diagnostic imaging
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Cerebral Hemorrhage / etiology
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Cerebral Hemorrhage / metabolism*
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Female
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Humans
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Male
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Middle Aged
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Positron-Emission Tomography
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Protein Binding
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Verapamil / metabolism
Substances
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Carbon Radioisotopes
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Verapamil