Abstract
Streptomycetes were isolated out of a soil sample taken from the rhizosphere of a spruce stand and screened by HPLC-diode array analysis for the production of secondary metabolites. This led to the detection of silvalactam, a novel 24-membered macrolactam antibiotic in extracts of Streptomyces strain Tü 6392. The structure was determined by MS and NMR spectroscopy experiments. Silvalactam shows a potent antiproliferative activity against various cancerous and non-cancerous cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Cell Line
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Chromatography, High Pressure Liquid
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Glycosides / chemistry
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Glycosides / isolation & purification
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Glycosides / pharmacology*
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Humans
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Lactams / chemistry
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Lactams / isolation & purification
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Lactams / pharmacology*
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Magnetic Resonance Spectroscopy / methods
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Mass Spectrometry / methods
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Neoplasms / drug therapy*
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Neoplasms / pathology
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Rhizosphere
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Soil Microbiology
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Streptomyces / metabolism*
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents
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Glycosides
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Lactams
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silvalactam