Catalyst-free and solvent-free Michael addition of 1,3-dicarbonyl compounds to nitroalkenes by a grinding method

Beilstein J Org Chem. 2012:8:534-8. doi: 10.3762/bjoc.8.61. Epub 2012 Apr 11.

Abstract

An environmentally benign, fast and convenient protocol has been developed for the Michael addition of 1,3-dicarbonyl compounds to β-nitroalkenes in good to excellent yields by a grinding method under catalyst- and solvent-free conditions.

Keywords: Michael addition; catalyst-free; grinding; solvent-free.