Quinolone-resistant Escherichia coli O127a:K63 serotype with an extended-spectrum-beta-lactamase phenotype from a food poisoning outbreak in China

J Clin Microbiol. 2012 Jul;50(7):2450-1. doi: 10.1128/JCM.00276-12. Epub 2012 May 2.

Abstract

We report an atypical enteropathogenic Escherichia coli O127a:K63 strain with resistance to quinolones and extended-spectrum cephalosporins isolated from a 2010 food poisoning outbreak involving 112 adults in China. Two resistance genes [bla(CTX-M-15), aac(6')-Ib-c] and five mutations (two in gyrA, two in parC, one in parE) coexisted in this enteropathogenic E. coli strain.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Anti-Bacterial Agents / pharmacology*
  • Cephalosporins / pharmacology*
  • China / epidemiology
  • Disease Outbreaks
  • Drug Resistance, Bacterial
  • Escherichia coli / drug effects*
  • Escherichia coli / enzymology
  • Escherichia coli / isolation & purification
  • Escherichia coli Infections / epidemiology*
  • Escherichia coli Infections / microbiology
  • Female
  • Foodborne Diseases / epidemiology*
  • Foodborne Diseases / microbiology
  • Genes, Bacterial
  • Genotype
  • Humans
  • Male
  • Phenotype
  • Quinolones / pharmacology*
  • Young Adult
  • beta-Lactamases / metabolism*

Substances

  • Anti-Bacterial Agents
  • Cephalosporins
  • Quinolones
  • beta-Lactamases