Synthesis and characterization of a paramagnetic sialic acid conjugate as probe for magnetic resonance applications

Carbohydr Res. 2012 Jun 1:354:21-31. doi: 10.1016/j.carres.2012.03.002. Epub 2012 Mar 17.

Abstract

Magnetic Resonance Imaging (MRI) using paramagnetic systems as contrast agents is receiving increased attention as diagnostic tool in the clinic. At the same time, NMR of paramagnetic systems can also be applied in biochemical fields; for example, the use of Paramagnetic Relaxation Enhancement (PRE) allows structure refinement and the analysis of transient dynamic processes involved in macromolecular complex formation. Herein we report the synthesis and computational characterization of a new DOTA-like sialic acid conjugate, which can be used both in MRI and PRE applications when coordinated to a suitable paramagnetic metal.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Contrast Media / chemical synthesis
  • Contrast Media / chemistry*
  • Heterocyclic Compounds, 1-Ring / chemistry*
  • Magnetic Resonance Imaging*
  • Models, Molecular
  • Molecular Dynamics Simulation
  • Molecular Structure
  • Organometallic Compounds / chemical synthesis
  • Organometallic Compounds / chemistry*
  • Sialic Acids / chemical synthesis
  • Sialic Acids / chemistry*

Substances

  • Contrast Media
  • Heterocyclic Compounds, 1-Ring
  • Organometallic Compounds
  • Sialic Acids
  • 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid