iPSCs from cancer cells: challenges and opportunities

Trends Mol Med. 2012 May;18(5):245-7. doi: 10.1016/j.molmed.2012.04.001. Epub 2012 Apr 20.

Abstract

Reprogramming and oncogenic transformation are stepwise processes that share many similarities, and induced pluripotent stem cells (iPSCs) generated from cancer cells could illuminate molecular mechanisms underlying the pathogenesis of human cancer. Deciphering the barriers underlying the reprogramming process of primary cancer cells could reveal information on the links between pluripotency and oncogenic transformation that would be instrumental for therapy development.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Differentiation
  • Cellular Reprogramming
  • Humans
  • Induced Pluripotent Stem Cells / cytology*
  • Induced Pluripotent Stem Cells / metabolism
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Neoplasms / pathology*
  • Neoplasms / physiopathology
  • Transcription Factors / genetics
  • Transcription Factors / metabolism

Substances

  • Transcription Factors