OXA-163-producing Klebsiella pneumoniae in Cairo, Egypt, in 2009 and 2010

J Clin Microbiol. 2012 Jul;50(7):2489-91. doi: 10.1128/JCM.06710-11. Epub 2012 Apr 18.

Abstract

Two genetically unrelated OXA-163-carrying Klebsiella pneumoniae strains were identified from two infection cases in June 2009 and May 2010 in Cairo, Egypt. OXA-163-producing Enterobacteriaceae had been previously reported in Argentina only. Both patients had no history of travel abroad. The emergence of this newly recognized OXA-48-related β-lactamase able to hydrolyze cephalosporins and carbapenems is especially worrying in a geographic area where OXA-48 is endemic and effective surveillance for antibiotic resistance is largely unaffordable.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Bacterial Agents / metabolism
  • Carbapenems / metabolism
  • Cephalosporins / metabolism
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • Egypt / epidemiology
  • Female
  • Humans
  • Hydrolysis
  • Klebsiella Infections / drug therapy
  • Klebsiella Infections / epidemiology
  • Klebsiella Infections / microbiology*
  • Klebsiella pneumoniae / drug effects
  • Klebsiella pneumoniae / enzymology*
  • Klebsiella pneumoniae / isolation & purification*
  • Male
  • Molecular Sequence Data
  • Sequence Analysis, DNA
  • beta-Lactam Resistance
  • beta-Lactamases / genetics*

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • Cephalosporins
  • DNA, Bacterial
  • beta-Lactamases

Associated data

  • GENBANK/JQ660370
  • GENBANK/JQ660371
  • GENBANK/JQ660372