Acquired patch-type blue nevus with overlying vitiligo: a case report

Int J Dermatol. 2012 May;51(5):568-70. doi: 10.1111/j.1365-4632.2011.05089.x.

Abstract

Background: Blue nevi are a group of congenital and acquired dermal melanocytoses characterized by a blue-gray appearance on the skin. The common blue nevus and cellular blue nevus are the most common subtypes. Patch-type blue nevus is rather rare.

Observations: We describe a 77-year-old Chinese male with a 6 × 8-cm non-palpable blue patch overlaid by a depigmented patch on the back of the left scalp. Histological examination of the blue-gray patch showed numerous spindled and elongated bipolar dendritic melanocytes in the upper reticular dermis and an absence of epidermal melanocytes. Immunohistochemically, these dendritic melanocytes were positive for S-100 and HMB-45. A diagnosis of a patch-type blue nevus with overlying vitiligo was made after the biopsy.

Conclusions: The patient presents an unusual manifestation of patch-type blue nevi with overlying vitiligo. To the best of our knowledge, these features have not been previously described.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Head and Neck Neoplasms / complications
  • Head and Neck Neoplasms / metabolism
  • Head and Neck Neoplasms / pathology*
  • Humans
  • Male
  • Melanoma-Specific Antigens / metabolism
  • Nevus, Blue / complications
  • Nevus, Blue / metabolism
  • Nevus, Blue / pathology*
  • S100 Proteins / metabolism
  • Scalp / pathology*
  • Skin Neoplasms / complications
  • Skin Neoplasms / metabolism
  • Skin Neoplasms / pathology*
  • Vitiligo / complications
  • Vitiligo / pathology*
  • gp100 Melanoma Antigen

Substances

  • Melanoma-Specific Antigens
  • PMEL protein, human
  • S100 Proteins
  • gp100 Melanoma Antigen