Anemia is associated with mortality following endovascular repair of abdominal aortic aneurysm

Vasc Endovascular Surg. 2012 Apr;46(3):223-8. doi: 10.1177/1538574412442251. Epub 2012 Apr 9.

Abstract

Aim: The aim of this study was to compare midterm mortality between anemic and nonanemic patients undergoing endovascular repair of abdominal aortic aneurysm and to assess a correlation with markers of inflammation.

Methods: Anemia was defined as hemoglobin <13 (men) and <12 g/dL (women). The impact of anemia and inflammatory markers on mortality was assessed using Kaplan-Meier curves and Cox regression.

Results: A total of 224 patients (12 females [5.36%]; age: 69.73 ± 8.72 years) were included; 102 (45.53%) were anemic. Median follow-up was 17 months (interquartile range: 7-25 months). Nine patients died (1.79%; 8 anemic vs 1 nonanemic). Survival was lower for patients with anemia (log-rank, P = .01). White blood cell count and C-reactive protein (CRP) differed significantly (P < .001 and P = .01). Anemia and CRP were associated with decreased survival (Cox regression, P = .01, hazard ratio [HR]: 0.35, 95% confidence interval: 0.14-0.84 and P = .002, HR: 1.18, 95% CI: 1.06-1.31).

Conclusion: Patients with anemia had decreased survival over the midterm; inflammatory markers were higher among this group.

MeSH terms

  • Aged
  • Anemia / blood
  • Anemia / mortality*
  • Aortic Aneurysm, Abdominal / blood
  • Aortic Aneurysm, Abdominal / mortality
  • Aortic Aneurysm, Abdominal / surgery*
  • Biomarkers / blood
  • Blood Vessel Prosthesis Implantation / adverse effects
  • Blood Vessel Prosthesis Implantation / mortality*
  • C-Reactive Protein / metabolism
  • Comorbidity
  • Endovascular Procedures / adverse effects
  • Endovascular Procedures / mortality*
  • Female
  • Humans
  • Inflammation Mediators / blood
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Proportional Hazards Models
  • Prospective Studies
  • Registries
  • Risk Assessment
  • Risk Factors
  • Time Factors
  • Treatment Outcome
  • United Kingdom / epidemiology
  • Up-Regulation

Substances

  • Biomarkers
  • Inflammation Mediators
  • C-Reactive Protein