Sensitivity of whole blood clotting time and activated partial thromboplastin time for factor IX: relevance to gene therapy and determination of post-transfusion elimination time of canine factor IX in hemophilia B dogs

J Thromb Haemost. 2012 Mar;10(3):474-6. doi: 10.1111/j.1538-7836.2011.04613.x.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Blood Coagulation* / drug effects
  • Blood Coagulation* / genetics
  • Coagulants / administration & dosage*
  • Coagulants / pharmacokinetics
  • Disease Models, Animal
  • Dogs
  • Enzyme-Linked Immunosorbent Assay
  • Factor IX / administration & dosage*
  • Factor IX / genetics*
  • Factor IX / pharmacokinetics
  • Genetic Therapy*
  • Hemophilia A / blood
  • Hemophilia A / genetics
  • Hemophilia A / therapy*
  • Metabolic Clearance Rate
  • Partial Thromboplastin Time*
  • Predictive Value of Tests
  • Sensitivity and Specificity
  • Whole Blood Coagulation Time*

Substances

  • Coagulants
  • Factor IX