Fractionated total body irradiation for bone marrow transplantation: clinical results on 66 patients

Radiother Oncol. 1990:18 Suppl 1:151-4. doi: 10.1016/0167-8140(90)90198-6.

Abstract

Short term clinical results of bone marrow transplantation on 66 patients conditioned with fractionated total body irradiation (12 Gy in 6 fractions and 3 days) are presented here. An acute toxic effects incident, similar to that obtained previously, a 27.6% interstitial pneumonitis associated with acute severe graft versus host disease in 77% of cases, 19.2% relapses, and 41% total crude survival with an actuarial probability of surviving for more than two years of 46% for ALL, 64% for AML and 28% for CML, are the results obtained since now.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Bone Marrow Transplantation*
  • Child
  • Clinical Protocols
  • Combined Modality Therapy
  • Female
  • Graft vs Host Disease / epidemiology*
  • Humans
  • Leukemia / radiotherapy*
  • Leukemia / surgery
  • Lymphoma / radiotherapy*
  • Lymphoma / surgery
  • Male
  • Middle Aged
  • Pulmonary Fibrosis / epidemiology*
  • Radiation Tolerance
  • Retrospective Studies
  • Whole-Body Irradiation / adverse effects*
  • Whole-Body Irradiation / methods