We compare by simulation the performance of 100 Gbit/s PDM-iRZ-QPSK and PS-QPSK transmission both in homogeneous and hybrid QPSK/OOK DM links. We detail the reasons of the overall performance investigating each nonlinear effect (SPM, XPM and XPolM) individually. Moreover, we compare the accuracy of the noise loading method with the more realistic use of noisy in-line amplifiers. Results shows that i) PDM-iRZ-QPSK and PS-QPSK have same reach in both homogeneous and hybrid setups, ii) correct simulations must include distributed ASE.