Effects of L-leucine in 5q- syndrome and other RPS14-deficient erythroblasts

Leukemia. 2012 Sep;26(9):2154-8. doi: 10.1038/leu.2012.82. Epub 2012 Mar 20.
No abstract available

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anemia, Macrocytic / genetics*
  • Anemia, Macrocytic / metabolism
  • Anemia, Macrocytic / pathology
  • Case-Control Studies
  • Cell Differentiation
  • Cell Proliferation
  • Chromosome Deletion
  • Chromosomes, Human, Pair 5 / genetics
  • Chromosomes, Human, Pair 5 / metabolism
  • Cri-du-Chat Syndrome / genetics*
  • Erythroblasts / metabolism*
  • Erythroblasts / pathology*
  • Flow Cytometry
  • Humans
  • Leucine / pharmacology*
  • Polymerase Chain Reaction
  • Protein Biosynthesis / drug effects
  • RNA, Messenger / genetics
  • RNA, Small Interfering / genetics
  • Ribosomal Proteins / antagonists & inhibitors
  • Ribosomal Proteins / genetics
  • Ribosomal Proteins / metabolism*
  • Trisomy / genetics*

Substances

  • RNA, Messenger
  • RNA, Small Interfering
  • RPS14 protein, human
  • Ribosomal Proteins
  • Leucine

Supplementary concepts

  • Chromosome 5, trisomy 5q
  • Chromosome 5q Deletion Syndrome