Abstract
LRRK2 was recently identified as a major susceptibility gene for Crohn's disease (CD) by genome-wide association studies (GWAS). LRRK2 deficiency in mice confers enhanced susceptibility to experimental colitis. In this research highlight, we discuss the current understanding of LRRK2 in the context of colitis, and postulate the future directions.
Publication types
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Research Support, N.I.H., Intramural
MeSH terms
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Animals
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Colitis / genetics
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Colitis / metabolism
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Humans
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Inflammatory Bowel Diseases / genetics
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Inflammatory Bowel Diseases / metabolism*
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Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
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Protein Serine-Threonine Kinases / genetics
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Protein Serine-Threonine Kinases / metabolism*
Substances
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LRRK2 protein, human
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Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
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Lrrk2 protein, mouse
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Protein Serine-Threonine Kinases