T-cell lymphoma/Sézary syndrome in a liver transplant recipient

J Cutan Med Surg. 2012 Jan-Feb;16(1):68-71. doi: 10.1177/120347541201600114.

Abstract

Background: Cutaneous T-cell lymphoma is a rare subtype of posttransplantation lymphoproliferative disease, with only 29 cases reported in the literature to date, the majority of which are post-renal transplantation. Only a few were reported after pancreas, heart, and bone marrow transplantation. There have been no reports of cutaneous T-cell lymphoma following liver transplantation to date.

Objective: We report a case of a 76-year-old male who developed generalized eczematous eruption 13 years after a liver transplantation. Investigations showed that it was Epstein-Barr virus-negative, CD3-positive, and CD4-positive cutaneous T-cell lymphoma with Sézary cells in the blood.

Conclusion: This shows that cutaneous T-cell lymphoma/Sézary syndrome can also develop after liver transplantation. To our knowledge, there are no similar reports in the English literature.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Eczema / etiology
  • Humans
  • Immunohistochemistry
  • Liver Cirrhosis / surgery
  • Liver Transplantation / adverse effects*
  • Liver Transplantation / immunology
  • Male
  • Sezary Syndrome / diagnosis
  • Sezary Syndrome / etiology*
  • Sezary Syndrome / immunology
  • Sezary Syndrome / metabolism
  • Sezary Syndrome / pathology
  • Skin Neoplasms / etiology*
  • Skin Neoplasms / immunology
  • Skin Neoplasms / metabolism
  • Skin Neoplasms / pathology
  • Time Factors