Using graphene oxide high near-infrared absorbance for photothermal treatment of Alzheimer's disease

Adv Mater. 2012 Apr 3;24(13):1722-8. doi: 10.1002/adma.201104864. Epub 2012 Mar 7.

Abstract

A novel strategy to dissociate amyloid aggregation is presented, using localised heat generation from a clinically used amyloid staining dye, thioflavin-S (ThS)-modified graphene oxide (GO) under NIR laser irradiation. Compared to traditional chemotherapies, photothermal therapy shows reduced side effects and improved selectivity and safety.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / metabolism
  • Alzheimer Disease / therapy*
  • Amyloid / metabolism*
  • Animals
  • Benzothiazoles
  • Cell Survival / drug effects
  • Graphite / chemistry
  • Graphite / pharmacology
  • Graphite / therapeutic use*
  • Humans
  • Hyperthermia, Induced / methods*
  • Mice
  • Nanostructures / chemistry
  • Oxides / chemistry
  • Oxides / pharmacology
  • Oxides / therapeutic use*
  • PC12 Cells
  • Phototherapy / methods*
  • Rats
  • Thiazoles / chemistry
  • Thiazoles / pharmacology
  • Thiazoles / therapeutic use*

Substances

  • Amyloid
  • Benzothiazoles
  • Oxides
  • Thiazoles
  • thioflavin T
  • Graphite