36 patients with 432 menstrual cycles and primary dysmenorrhea were treated with Piroxicam-Jenapharm. Piroxicam-Jenapharm was given in a dose of 40 mg once daily for the first 2 days followed by 20 mg once daily. Piroxicam, a nonsteroidal-anti-inflammatory drug (NSAID) is an effective drug in reducing menstrual pain intensity in 80%. Piroxicam was well tolerated with no patient reporting side-effects. The treatment of primary dysmenorrhea with total 100 mg Piroxicam-Jenapharm over 3 days is recommended.