Abstract
Cutis laxa is a rare disorder of elastic tissue resulting in loose, redundant, hypoelastic skin. Both acquired and inherited forms exist, some of which have significant systemic manifestations. Here, we review the various forms of cutis laxa, with focus on the inherited forms. Recent molecular studies have provided many new insights into the causes of cutis laxa and revealed greater genetic heterogeneity than previously appreciated.
Copyright © 2011 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Abnormalities, Multiple / diagnosis
-
Abnormalities, Multiple / epidemiology
-
Abnormalities, Multiple / genetics
-
Biopsy, Needle
-
Cutis Laxa / epidemiology
-
Cutis Laxa / genetics*
-
Cutis Laxa / pathology*
-
Elastic Tissue / pathology
-
Extracellular Matrix Proteins / genetics*
-
Female
-
Genetic Predisposition to Disease / epidemiology*
-
Humans
-
Immunohistochemistry
-
Incidence
-
Male
-
Prognosis
-
Risk Assessment
-
Severity of Illness Index
Substances
-
EFEMP2 protein, human
-
Extracellular Matrix Proteins
-
FBLN5 protein, human