Abstract
We report the first known case of a breakthrough pulmonary infection caused by Aspergillus nomius in an acute myeloid leukemia patient receiving caspofungin therapy. The isolate was identified using matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS) and sequencing-based methods. The organism was found to be fully susceptible, in vitro, to echinocandin antifungal agents.
MeSH terms
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Aged
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Antifungal Agents / administration & dosage
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Aspergillus / chemistry
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Aspergillus / classification
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Aspergillus / genetics
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Aspergillus / isolation & purification*
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Caspofungin
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Echinocandins / administration & dosage
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Humans
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Leukemia, Myeloid, Acute / complications*
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Lipopeptides
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Male
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Microbial Sensitivity Tests
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Microscopy
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Mycology / methods
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Phylogeny
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Pulmonary Aspergillosis / diagnosis*
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Pulmonary Aspergillosis / microbiology
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Pulmonary Aspergillosis / pathology*
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Sequence Analysis, DNA
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Substances
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Antifungal Agents
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Echinocandins
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Lipopeptides
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Caspofungin