One-pot synthesis of a piperidine-based rigidified DTPA analogue and its bifunctional chelating agent

Org Biomol Chem. 2012 Apr 7;10(13):2525-7. doi: 10.1039/c2ob07154a. Epub 2012 Feb 20.

Abstract

The core structure of cis-3,5-diaminopiperidine was N-alkylated with excess t-butylbromoacetate in order to exploit the successive N-quaternarization and Stevens rearrangement to access the pentaalkylated product and the bifunctional chelating agent containing a N-butanedioic acid pendant arm at the same time. The relaxometric properties of the Gd(III) complexes with these ligands were studied also in terms of pH and serum stabilities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkylation
  • Chelating Agents / chemical synthesis*
  • Ligands
  • Molecular Structure
  • Pentetic Acid / analogs & derivatives*
  • Piperidines / chemistry*

Substances

  • Chelating Agents
  • Ligands
  • Piperidines
  • piperidine
  • Pentetic Acid