aSIRTing control over cancer stem cells

Takahiro Ito; Bryan Zimdahl; Tannishtha Reya

doi:10.1016/j.ccr.2012.01.014

aSIRTing control over cancer stem cells

Cancer Cell. 2012 Feb 14;21(2):140-2. doi: 10.1016/j.ccr.2012.01.014.

Authors

Takahiro Ito¹, Bryan Zimdahl, Tannishtha Reya

Affiliation

¹ Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, CA 92093, USA.

PMID: 22340585
DOI: 10.1016/j.ccr.2012.01.014

Abstract

Cancer stem cells lie at the root of chronic myelogenous leukemia (CML) and mediate its continued growth. Their resistance to current therapies results in an inability to eradicate the disease. In this issue of Cancer Cell, Li et al. identify SIRT1 as a new target for eliminating CML cancer stem cells.

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