Abstract
Eleven new dibenzocyclooctadiene lignans, polysperlignans A-K (1-11), and eight known analogues (12-19) were isolated from the stems of Kadsura polysperma. Their structures and absolute configurations were established using a combination of MS, NMR, CD, and single-crystal X-ray diffraction techniques. Selected compounds were evaluated for activity against β-amyloid- or hydrogen peroxide-induced neurotoxicity on PC12 cells, and 1, 2, 4, 5, 13, and 16 showed statistically significant neuroprotective effects in these in vitro assays.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Crystallography, X-Ray
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Cyclooctanes / chemistry
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Cyclooctanes / isolation & purification*
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Cyclooctanes / pharmacology*
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology*
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Hydrogen Peroxide / pharmacology
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Kadsura / chemistry*
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Lignans / chemistry
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Lignans / isolation & purification*
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Lignans / pharmacology*
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Molecular Conformation
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Molecular Structure
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / isolation & purification*
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Neuroprotective Agents / pharmacology*
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Nuclear Magnetic Resonance, Biomolecular
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Plant Stems / chemistry
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Rats
Substances
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Cyclooctanes
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Drugs, Chinese Herbal
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Lignans
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Neuroprotective Agents
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dibenzocyclooctadiene lignan
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Hydrogen Peroxide