Increased levels of CD4 T-cell activation in individuals with CXCR4 using viruses in primary HIV-1 infection

AIDS. 2012 Apr 24;26(7):887-90. doi: 10.1097/QAD.0b013e328351e721.

Abstract

CXCR4-tropic (X4) HIV-1 variants are associated with faster disease progression compared with CCR5-tropic variants; however, the mechanism for this is unclear. We measured T-cell activation in 120 individuals with primary HIV-1 infection. X4-utilizing variants, determined genotypically, were present in 8.3% of the participants and were associated with higher levels of CD4 T-cell activation, even after adjusting for other prognostic factors. Increased CD4 T-cell activation may influence the more rapid immunological decline associated with X4 virus.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers / metabolism
  • CD4-Positive T-Lymphocytes / immunology*
  • CD4-Positive T-Lymphocytes / metabolism
  • Disease Progression
  • Female
  • HIV Infections / immunology*
  • HIV Infections / virology
  • HIV-1 / genetics
  • HIV-1 / immunology*
  • Humans
  • Lymphocyte Activation / immunology*
  • Male
  • Receptors, CCR5 / immunology
  • Receptors, CXCR4 / immunology*
  • Receptors, CXCR4 / physiology

Substances

  • Biomarkers
  • CXCR4 protein, human
  • Receptors, CCR5
  • Receptors, CXCR4