Synthesis and antitumor activities of platinum complexes of unsymmetrical alicyclic diamines as carrier ligands

J Pharm Sci. 1990 Aug;79(8):750-3. doi: 10.1002/jps.2600790819.

Abstract

The synthesis and biological activities of the platinum complexes of 2-aminomethylaziridine, 2-aminomethylazetidine, 2-aminomethylpyrrolidine, 2-aminomethylpiperidine as carrier ligands are described. The platinum complexes of 2-aminomethylazetidine and 2-aminomethylpyrrolidine are significantly effective against murine tumors. In particular, 2-aminomethylazetidine (1,1-cyclobutanedicarboxylato)platinum II (13) and 2-aminomethylpyrrolidine(1,1-cyclobutanedicarboxylato)platin um II (16) exhibited potent antitumor activity and were soluble in water, and their antitumor activities against Colon 26 carcinoma (sc-ip system) were superior to CBDCA and comparable to CDDP.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Carcinoma / drug therapy
  • Colonic Neoplasms / drug therapy
  • Diamines / chemical synthesis*
  • Diamines / pharmacology
  • Drug Carriers
  • Leukemia P388 / drug therapy
  • Ligands
  • Male
  • Mice
  • Mice, Inbred Strains
  • Organoplatinum Compounds / chemical synthesis*

Substances

  • Antineoplastic Agents
  • Diamines
  • Drug Carriers
  • Ligands
  • Organoplatinum Compounds