Cu(I)-catalyzed (11)C carboxylation of boronic acid esters: a rapid and convenient entry to (11)C-labeled carboxylic acids, esters, and amides

Angew Chem Int Ed Engl. 2012 Mar 12;51(11):2698-702. doi: 10.1002/anie.201107263. Epub 2012 Feb 3.

Abstract

Rapid and direct: the carboxylation of boronic acid esters with (11)CO(2) provides [(11)C]carboxylic acids as a convenient entry into [(11)C]esters and [(11)C]amides. This conversion of boronates is tolerant to diverse functional groups (e.g., halo, nitro, or carbonyl).

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemistry*
  • Boronic Acids / chemistry*
  • Carbon Dioxide / chemistry
  • Carbon Radioisotopes / chemistry
  • Carboxylic Acids / chemical synthesis
  • Carboxylic Acids / chemistry*
  • Catalysis
  • Copper / chemistry*
  • Esters
  • Isotope Labeling

Substances

  • Amides
  • Boronic Acids
  • Carbon Radioisotopes
  • Carboxylic Acids
  • Esters
  • Carbon Dioxide
  • Copper