Glutamate dehydrogenase is highly conserved among Clostridium difficile ribotypes

J Clin Microbiol. 2012 Apr;50(4):1425-6. doi: 10.1128/JCM.05600-11. Epub 2012 Feb 1.

Abstract

gluD was highly conserved and glutamate dehydrogenase (GDH) was readily expressed in vitro by all 77 Clostridium difficile ribotypes assayed. All ribotypes, including ARL 002, ARL 027, and ARL 106, were reactive in assays that detect C. difficile GDH.

MeSH terms

  • Amino Acid Sequence
  • Amino Acid Substitution
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / genetics*
  • Clostridioides difficile / enzymology*
  • Clostridioides difficile / genetics
  • Conserved Sequence*
  • Glutamate Dehydrogenase / chemistry
  • Glutamate Dehydrogenase / genetics*
  • Ribotyping
  • Sequence Analysis, DNA
  • Sequence Analysis, Protein

Substances

  • Bacterial Proteins
  • Glutamate Dehydrogenase