Nuclease cleavage-assisted target recycling for signal amplification of free-label impedimetric aptasensors

Chem Commun (Camb). 2012 Mar 7;48(20):2627-9. doi: 10.1039/c2cc17536c. Epub 2012 Feb 1.

Abstract

A simple, novel, label-free impedimetric aptasensor with signal amplification is developed for ultrasensitive detection of small molecules on a carbon nanotubes-based sensing platform by combining target-induced release of the aptamers and nuclease cleavage-assisted target recycling.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aptamers, Nucleotide / chemistry*
  • Biosensing Techniques / methods*
  • Deoxyribonucleases / chemistry*
  • Electrochemistry*
  • Nanotubes, Carbon / chemistry*
  • Staining and Labeling / methods*

Substances

  • Aptamers, Nucleotide
  • Nanotubes, Carbon
  • Deoxyribonucleases