[Apolipoprotein(a) isoforms immunoblotting detection: comparative study of two methods]

Ann Biol Clin (Paris). 2012 Jan-Feb;70(1):13-7. doi: 10.1684/abc.2011.0651.
[Article in French]

Abstract

This study reports the comparison between two methods (chemiluminescence and enzymatic colorimetry) for revelation of apolipoprotein(a) [apo(a)] isoforms by immunoblotting in 102 Ivorian healthy subjects. Apo(a) isoform sizes were determined by sodium dodecyl sulfate-agarose-polyacrylamide gel electrophoresis (SDS-PAGE) followed by immunoblotting using enzymatic colorimetry or chemiluminescence. Within-run precision was comprised between 4.9% and 9.2% for colorimetry and between 2.9% and 4.6% for chemiluminescence. Both methods have detected apo(a) isoforms in all patients, even when lipoprotein(a) concentrations were under detection limit (0.02 g/L). The two methods were significantly correlated (r = 0.96 to 0.98, p<0.0001). Even though the chemiluminescence method exhibited better performances than the colorimetric method, both techniques could be used indifferently.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Adolescent
  • Adult
  • Apoprotein(a) / analysis*
  • Apoprotein(a) / blood
  • Apoprotein(a) / metabolism*
  • Blood Donors
  • Colorimetry / methods
  • Cote d'Ivoire
  • Electrophoresis, Polyacrylamide Gel
  • Humans
  • Immunoblotting / methods*
  • Luminescent Measurements / methods
  • Middle Aged
  • Molecular Weight
  • Protein Isoforms / analysis
  • Protein Isoforms / metabolism
  • Sensitivity and Specificity
  • Young Adult

Substances

  • Protein Isoforms
  • Apoprotein(a)