Multi-scale modelling of elastic moduli of trabecular bone

J R Soc Interface. 2012 Jul 7;9(72):1654-73. doi: 10.1098/rsif.2011.0814. Epub 2012 Jan 25.

Abstract

We model trabecular bone as a nanocomposite material with hierarchical structure and predict its elastic properties at different structural scales. The analysis involves a bottom-up multi-scale approach, starting with nanoscale (mineralized collagen fibril) and moving up the scales to sub-microscale (single lamella), microscale (single trabecula) and mesoscale (trabecular bone) levels. Continuum micromechanics methods, composite materials laminate theory and finite-element methods are used in the analysis. Good agreement is found between theoretical and experimental results.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aged, 80 and over
  • Elasticity / physiology*
  • Epiphyses / physiology*
  • Epiphyses / ultrastructure*
  • Humans
  • Male
  • Models, Biological*
  • Tibia / physiology*
  • Tibia / ultrastructure*