Panowamycins A and B, new antitrypanosomal isochromans produced by Streptomyces sp. K07-0010

J Antibiot (Tokyo). 2012 Apr;65(4):197-202. doi: 10.1038/ja.2011.139. Epub 2012 Jan 25.

Abstract

Two new isochromans, panowamycins A and B, were purified by solvent extraction, silica gel and octadecylsilyl silica gel (ODS) column chromatography followed by preparative HPLC, from a culture broth of Streptomyces sp. K07-0010, together with the known compounds NFAT-133, conglobatin, piericidin C series and dinactin. Structures of panowamycins were elucidated as new analogs of NFAT-133 by spectroscopic studies including various NMR experiments. Panowamycins A and B showed moderate antitrypanosomal activity, with IC(50) values of 0.40 and 3.30 μg ml(-1), respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiprotozoal Agents / chemistry
  • Antiprotozoal Agents / isolation & purification*
  • Antiprotozoal Agents / pharmacology
  • Bangladesh
  • Cell Line
  • Cell Proliferation / drug effects
  • Chromans / chemistry
  • Chromans / isolation & purification*
  • Chromans / pharmacology
  • Humans
  • Inhibitory Concentration 50
  • Microscopy, Electron, Scanning
  • Models, Molecular
  • Nuclear Magnetic Resonance, Biomolecular
  • Spectrometry, Mass, Fast Atom Bombardment
  • Spectrophotometry, Infrared
  • Streptomyces / chemistry*
  • Streptomyces / metabolism
  • Streptomyces / ultrastructure
  • Trypanosoma brucei brucei / drug effects

Substances

  • Antiprotozoal Agents
  • Chromans