Compatibility of acupoints is an important component of acupuncture prescription, and it is the key point to achieve the therapeutic effect of acupuncture. Antagonism and synergism are held as two possible results of acupoints compatibility. Recent literatures are summarized and analyzed in this article. And clinical trials and laboratorial studies indicate that antagonism is a result of acupoints compatibility. However, since the relative studies are not enough, extensive attentions are not aroused among researchers. Therefore, in the future studies, based on specificity of acupoints, interdisciplinary research methods should be adopted to explore the effect of antagonism of acupoint compatibility on enhancing the clinical therapeutic effect and expound the mechanism of acupuncture and moxibustion. It is considered to be a significant topic which is worth to be deeply studied.