Abstract
Leucine-rich repeat kinase 2 (LRRK2) is linked to various diseases, including Parkinson's disease, cancer, and leprosy. Data from LRRK2 knockout mice has highlighted a possible role for LRRK2 in regulating signaling pathways that are linked to the pathogenesis of Crohn's disease. Here, we examine how LRRK2's role as a signaling hub in the cell could lead to diverse pathologies.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Crohn Disease / metabolism
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Disease Models, Animal
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Gene Expression Regulation
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Humans
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Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
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Mice
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Mice, Knockout
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Models, Biological
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Models, Genetic
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Neurons / metabolism
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Parkinson Disease / metabolism
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Protein Serine-Threonine Kinases / metabolism*
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Protein Serine-Threonine Kinases / physiology*
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Protein Structure, Tertiary
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Signal Transduction
Substances
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LRRK2 protein, human
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Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
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Lrrk2 protein, mouse
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Protein Serine-Threonine Kinases