Abstract
Lassa virus (LASV) is the causative agent of Lassa hemorrhagic fever (LF) in humans, a deadly disease endemic to West Africa that results in 5,000 to 10,000 deaths annually. Here we present results demonstrating that functional type I and type II interferon (IFN) signaling is required for efficient control of LASV dissemination and clearance.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Female
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Humans
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Interferons / immunology*
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Lassa Fever / immunology*
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Lassa Fever / virology
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Lassa virus / immunology*
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Lassa virus / physiology
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Male
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Mice
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Mice, Knockout
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Receptors, Interferon / genetics
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Receptors, Interferon / immunology
Substances
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Receptors, Interferon
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Interferons