Abstract
Screening of an expression library of Leptospira interrogans with eye fluids from uveitic horses resulted in identification of a novel protein, LruC. LruC is located in the inner leaflet of the leptospiral outer membrane, and an lruC gene was detected in all tested pathogenic L. interrogans strains. LruC-specific antibody levels were significantly higher in eye fluids and sera of uveitic horses than healthy horses. These findings suggest that LruC may play a role in equine leptospiral uveitis.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Antibodies, Bacterial / analysis*
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Antibodies, Bacterial / blood
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Antigens, Bacterial / genetics
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Antigens, Bacterial / immunology
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Bacterial Outer Membrane Proteins / genetics
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Bacterial Outer Membrane Proteins / immunology
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Body Fluids / immunology*
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DNA, Bacterial / chemistry
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DNA, Bacterial / genetics
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Eye / immunology*
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Horse Diseases / immunology*
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Horse Diseases / pathology
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Horses
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Leptospira / immunology*
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Leptospira / pathogenicity
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Leptospirosis / immunology
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Leptospirosis / pathology
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Leptospirosis / veterinary*
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Molecular Sequence Data
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Sequence Analysis, DNA
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Uveitis / immunology
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Uveitis / pathology
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Uveitis / veterinary*
Substances
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Antibodies, Bacterial
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Antigens, Bacterial
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Bacterial Outer Membrane Proteins
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DNA, Bacterial