Priming effect of recombinant vaccinia virus coding for the middle hepatitis B surface antigen

E Hamsíková; H Závadová; L Kutinová; V Ludvíková; V Krchnák; S Némecková; V Vonka

doi:10.1007/BF01316681

Priming effect of recombinant vaccinia virus coding for the middle hepatitis B surface antigen

Arch Virol. 1990;113(3-4):283-9. doi: 10.1007/BF01316681.

Authors

E Hamsíková¹, H Závadová, L Kutinová, V Ludvíková, V Krchnák, S Némecková, V Vonka

Affiliation

¹ Department of Experimental Virology, Institute of Sera and Vaccines, Prague, Czechoslovakia.

PMID: 2222186
DOI: 10.1007/BF01316681

Abstract

Recombinant vaccinia virus expressing the middle hepatitis B virus surface antigen was incapable of inducing marked antibody response against the S and pre-S2 antigenic specifities in mice. However, mice immunized with this virus produced antibodies to both these antigens after the following administration of subtreshold doses of plasmatic hepatitis B surface antigen.

MeSH terms

Animals
Antibodies, Viral / biosynthesis
Hepatitis B Surface Antigens / genetics
Hepatitis B Surface Antigens / immunology*
Immunization
Mice
Protein Precursors / genetics
Protein Precursors / immunology
Vaccinia virus / genetics
Vaccinia virus / immunology*

Substances

Antibodies, Viral
Hepatitis B Surface Antigens
Protein Precursors
presurface protein 2, hepatitis B surface antigen