Effect of ribavirin on junin virus infection in guinea pigs

Zoonoses Public Health. 2012 Jun;59(4):278-85. doi: 10.1111/j.1863-2378.2011.01447.x. Epub 2012 Jan 2.

Abstract

Junin virus (JUNV) is the aetiological agent of Argentine haemorrhagic fever. The pathogenesis of the infection is not well understood, no licensed vaccines exist and no specific antiviral therapy is available. Previous studies have demonstrated the ability of ribavirin to delay and reduce JUNV disease and virus burden in guinea pigs without preventing death. Based on available data, we performed three different studies to determine the efficacy of ribavirin against JUNV in the guinea pig model with a focus on survival. Different doses and treatment schedules of ribavirin were tested in a lethal model of JUNV infection. Our results show that prolonged treatment with high doses of ribavirin significantly reduces the mortality in guinea pigs infected with JUNV. These results may be useful in future experimental studies or clinical testing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiviral Agents / therapeutic use*
  • Arenaviridae Infections / diagnosis
  • Arenaviridae Infections / drug therapy*
  • Arenaviridae Infections / mortality
  • Arenaviridae Infections / virology
  • Chlorocebus aethiops
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Female
  • Guinea Pigs
  • Junin virus / drug effects*
  • Junin virus / isolation & purification
  • Kaplan-Meier Estimate
  • Post-Exposure Prophylaxis
  • Ribavirin / therapeutic use*
  • Vero Cells

Substances

  • Antiviral Agents
  • Ribavirin