Abstract
Intravenous bolus mitomycin was given at a dose of 10-12 mg/m2 to patients with epithelial ovarian cancer resistant to cisplatin or carboplatin. There were three (12%) partial responses and no complete responses in the 25 patients so treated.
MeSH terms
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Adult
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Aged
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Carboplatin / therapeutic use*
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Carcinoma / drug therapy*
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Cisplatin / therapeutic use*
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Drug Evaluation
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Drug Resistance
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Female
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Humans
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Leukopenia / chemically induced
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Middle Aged
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Mitomycins / adverse effects
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Mitomycins / therapeutic use*
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Ovarian Neoplasms / drug therapy*
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Remission Induction
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Thrombocytopenia / chemically induced
Substances
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Mitomycins
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Carboplatin
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Cisplatin