A 78-year-old man referred to our hospital with the chief complaints of anorexia, general malaise, rash, and weight loss. Laboratory examination revealed pancytopenia, hyperglobulinemia, generalized adenopathy, and multiple pulmonary nodules. Video-assisted thoracic surgery (VATS) was performed to diagnose pulmonary nodules. After operation, it was difficult to achieve hemostasis for a while. Finally, the patient was diagnosed as pulmonary cryptococcosis and Evans syndrome.