The frontostriatal circuitry and behavioral complications in PD

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder traditionally associated with motor symptoms. However, a number of reports have described also deficits across a range of cognitive functions and behavioral complications during the progression of the disease. Here, we summarize recent observations that may help us to understand the underlying neuronal correlates of behavioral complications in PD. We will report findings from cutting-edge imaging technology which in the last few years have provided the bulk of information on the neurobiological underpinnings of non-motor symptoms in PD.