Abstract
The pharmacokinetics of 4-methyl-2,6-diisobornylphenol (MDIBP) in rat blood plasma has been studied after intravenous injection. The drug concentration in the plasma was determined using a reverse-phase HPLC procedure. It is shown that MDIBP rapidly penetrates into intensively perfused organs, but is slowly eliminated from the organism (MRT value amounting to 9 h).
MeSH terms
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Animals
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Antioxidants / administration & dosage
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Antioxidants / chemistry
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Antioxidants / pharmacokinetics*
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Camphanes / administration & dosage
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Camphanes / blood
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Camphanes / chemistry
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Camphanes / pharmacokinetics*
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Cresols / administration & dosage
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Cresols / blood
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Cresols / chemistry
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Cresols / pharmacokinetics*
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Injections, Intravenous
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Male
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Models, Biological*
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Organ Specificity
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Rats
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Rats, Wistar
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Tissue Distribution
Substances
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4-methyl-2,6-diisobornylphenol
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Antioxidants
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Camphanes
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Cresols