A near-infrared fluorescent probe for monitoring ozone and imaging in living cells

Chem Commun (Camb). 2012 Jan 18;48(5):684-6. doi: 10.1039/c1cc15844a. Epub 2011 Dec 1.

Abstract

A near-infrared fluorescent probe (Trp-Cy) for endogenous ozone is presented, which exhibited a large stokes shift about 140 nm and a rapid fluorescence response to ozone with high selectivity and sensitivity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carbocyanines / analysis*
  • Carbocyanines / chemical synthesis
  • Cell Line, Tumor
  • Fluorescent Dyes / analysis*
  • Fluorescent Dyes / chemical synthesis
  • Half-Life
  • Humans
  • Lung Neoplasms / metabolism*
  • Lung Neoplasms / pathology
  • Macrophages / cytology
  • Macrophages / drug effects
  • Macrophages / metabolism*
  • Magnetic Resonance Spectroscopy
  • Mice
  • Microscopy, Confocal
  • Molecular Imaging / methods*
  • Ozone / analysis*
  • Ozone / metabolism
  • Reactive Oxygen Species / analysis*
  • Reactive Oxygen Species / metabolism
  • Sensitivity and Specificity
  • Spectroscopy, Near-Infrared / methods
  • Tetradecanoylphorbol Acetate / pharmacology
  • Tryptophan / chemistry
  • Tryptophan / metabolism

Substances

  • Carbocyanines
  • Fluorescent Dyes
  • Reactive Oxygen Species
  • Ozone
  • Tryptophan
  • Tetradecanoylphorbol Acetate