Lipids, a missing link in prion propagation

Joaquín Castilla; Félix M Goñi

doi:10.1016/j.chembiol.2011.11.002

Lipids, a missing link in prion propagation

Chem Biol. 2011 Nov 23;18(11):1345-6. doi: 10.1016/j.chembiol.2011.11.002.

Authors

Joaquín Castilla¹, Félix M Goñi

Affiliation

¹ CIC bioGUNE, Parque Tecnológico de Bizkaia, Ed. 800, 48160 Derio, Spain.

PMID: 22118664
DOI: 10.1016/j.chembiol.2011.11.002

Abstract

Prion protein is considered to have an infectious ability by itself. However, in order to explain the main features of prion diseases, additional cofactors would be required. Sanghera et al. (in this issue of Chemistry and Biology) have found evidence that a ganglioside, GM1, is a ligand for the C-terminal region of prion protein.

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