A new angle on TCR activation

Jia-huai Wang; Ellis L Reinherz

doi:10.1016/j.immuni.2011.11.008

A new angle on TCR activation

Immunity. 2011 Nov 23;35(5):658-60. doi: 10.1016/j.immuni.2011.11.008.

Authors

Jia-huai Wang¹, Ellis L Reinherz

Affiliation

¹ Laboratory of Immunobiology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Functional cognate T cell recognition is mediated via the interaction of a T cell receptor complex with its pMHC ligand. Adams et al. (2011) in this issue of Immunity provide evidence that docking geometry may impact 2D binding and T cell activation.

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Abstract

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