PIP: There are indications that the status of hormone receptors in breast cancer tissue is related to the success of chemotherapy to treat breast cancer. Remissions are recorded in 60% of the cases of endocrine treatment of patients with positive evidence of cytoplasmic hormone receptors. It must be kept in mind, however, that any given cancer tissue sample is not representative for all metastases locations. Depending on the hormone receptor content of each section, different parts of the tumor could react differently to hormone treatment, and even sections with the same receptor content can react differently to treatment. The criteria for the determination of a remission are too strict. The carbon absorption method or the more common agargel electrophoresis can be used to determine the level of receptor content in a tissue sample.