Expanding the azaspiro[3.3]heptane family: synthesis of novel highly functionalized building blocks

Org Lett. 2012 Jan 6;14(1):66-9. doi: 10.1021/ol2028459. Epub 2011 Nov 23.

Abstract

The preparation of versatile azaspiro[3.3]heptanes carrying multiple exit vectors is disclosed. Expedient synthetic routes enable the straightforward access to these novel modules that are expected to have significance in drug discovery and design.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aza Compounds / chemical synthesis*
  • Ethers, Cyclic / chemistry
  • Heptanes / chemical synthesis*
  • Models, Molecular
  • Molecular Structure
  • Spiro Compounds / chemical synthesis*

Substances

  • Aza Compounds
  • Ethers, Cyclic
  • Heptanes
  • Spiro Compounds
  • oxetane