Discovery of a secreted tumor suppressor provides a promising therapeutic strategy for follicular lymphoma

Marc R Mansour; A Thomas Look

doi:10.1016/j.ccr.2011.10.027

Discovery of a secreted tumor suppressor provides a promising therapeutic strategy for follicular lymphoma

Cancer Cell. 2011 Nov 15;20(5):559-61. doi: 10.1016/j.ccr.2011.10.027.

Authors

Marc R Mansour¹, A Thomas Look

Affiliation

¹ Department of Pediatric Oncology, Dana-Farber Cancer Institute, Children's Hospital, Boston and Harvard Medical School, 450 Brookline Avenue, Boston, MA 02115, USA.

PMID: 22094251
DOI: 10.1016/j.ccr.2011.10.027

Abstract

In a recent paper in Cell, Oricchio et al. identify EPHA7 as a tumor suppressor gene residing in the 6q-deleted region in follicular lymphoma. A truncated EPHA7(TR) isoform is secreted by normal B cells, inhibits EPHA2 signaling, and, as a secreted tumor suppressor protein, has potential as a targeted therapeutic polypeptide.

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