Derepressing nuclear receptors for metabolic adaptation

Alan R Saltiel

doi:10.1016/j.cell.2011.10.027

Derepressing nuclear receptors for metabolic adaptation

Cell. 2011 Nov 11;147(4):717-8. doi: 10.1016/j.cell.2011.10.027.

Author

Alan R Saltiel¹

Affiliation

¹ Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA. saltiel@lsi.umich.edu

PMID: 22078871
DOI: 10.1016/j.cell.2011.10.027

Abstract

NCoR is a corepressor of several transcription factors, including the PPAR family of nuclear receptors in fat and muscle. By specifically deleting NCoR in these tissues, Li et al. and Yamamoto et al. now uncover an important role for NCoR in regulating lipid homeostasis through the coordinated control of different nuclear receptors.

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